Exogenous DNA interaction with rabbit sperm cells and its transfer into ova
has been studied. It was shown that rabbit sperm cells are able to capture
, hold, and transfer exogenous DNA to ova during fertilization. Sperm/DNA t
ransfer leads to genetically transformed offspring. Transfection efficiency
varied within a large range. Low expression and rearrangements of the tran
sgene were observed. (C) 2000 Wiley-Liss, Inc.