CTG triplet repeat expansion in a laryngeal carcinoma from a patient with myotonic dystrophy

Authors
Osanai, R Kinoshita, M Hirose, K Homma, T Kawabata, I
Citation
R. Osanai et al., CTG triplet repeat expansion in a laryngeal carcinoma from a patient with myotonic dystrophy, MUSCLE NERV, 23(5), 2000, pp. 804-806
Citations number
24
Categorie Soggetti
da verificare
Journal title
MUSCLE & NERVE
ISSN journal
0148639X → ACNP
Volume
23
Issue
5
Year of publication
2000
Pages
804 - 806
Database
ISI
SICI code
0148-639X(200005)23:5<804:CTREIA>2.0.ZU;2-R
Abstract
A 66-year-old Japanese man with myotonic dystrophy (DM) underwent total lar yngectomy for laryngeal carcinoma. The size of the expanded DNA fragment (E f) from the leukocytes and normal laryngeal tissues of this patient was onl y slightly longer than that in normal subjects. EF, however, was markedly l onger in the laryngeal carcinoma. These findings support the hypothesis tha t elongation of the CTG repeat in the DM kinase gene occurs during acquired cell proliferation. (C) 2000 John Wiley & Sons, Inc.