Maintaining imprinting

Authors
Mann, MRW Bartolomei, MS
Citation
Mrw. Mann et Ms. Bartolomei, Maintaining imprinting, NAT GENET, 25(1), 2000, pp. 4-5
Citations number
10
Categorie Soggetti
Molecular Biology & Genetics
Journal title
NATURE GENETICS
ISSN journal
10614036 → ACNP
Volume
25
Issue
1
Year of publication
2000
Pages
4 - 5
Database
ISI
SICI code
1061-4036(200005)25:1<4:MI>2.0.ZU;2-U
Abstract
The imprinting of a large cluster of paternally expressed genes at the Prad er-Willi syndrome locus is established by an imprinting centre in human and mouse. Deletions carried by a member of a rare family and by chimaeric mic e demonstrate that the imprinting centre is additionally required for postz ygotic maintenance of paternal identity.