Sec1 gets a grip on syntaxin

Authors
Hanson, PI
Citation
Pi. Hanson, Sec1 gets a grip on syntaxin, NAT ST BIOL, 7(5), 2000, pp. 347-349
Citations number
14
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NATURE STRUCTURAL BIOLOGY
ISSN journal
10728368 → ACNP
Volume
7
Issue
5
Year of publication
2000
Pages
347 - 349
Database
ISI
SICI code
1072-8368(200005)7:5<347:SGAGOS>2.0.ZU;2-3
Abstract
Neuronal-Sec1 and syntaxin 1a. two proteins essential for membrane fusion, have now been crystallized in a complex with each other. The structure show s how the horseshoe-shaped nSec1 surrounds and holds syntaxin in a new conf ormation, and suggests that conformational changes in both nSec1 and syntax in must take place for membrane fusion to proceed.