Creatine monohydrate in muscular dystrophies: A double-blind, placebo-controlled clinical study

The authors assessed the safety and efficacy of creatine monohydrate (Cr) i n various types of muscular dystrophies in a double-blind, crossover trial. Thirty-six patients (12 patients with facioscapulohumeral dystrophy, 10 pa tients with Becker dystrophy, 8 patients with Duchenne dystrophy, and 6 pat ients with sarcoglycan-deficient limb girdle muscular dystrophy) were rando mized to receive Cr or placebo for 8 weeks. There was mild but significant improvement in muscle strength and daily-life activities by Medical Researc h Council scales and the Neuromuscular Symptom Score. Cr was well tolerated throughout the study period.