Association of the N-acetyltransferase I gene (NATI) with mild and severe substance abuse

Authors
Comings, DE Muhleman, D Wu, SJ MacMurray, J
Citation
De. Comings et al., Association of the N-acetyltransferase I gene (NATI) with mild and severe substance abuse, NEUROREPORT, 11(6), 2000, pp. 1227-1230
Citations number
22
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROREPORT
ISSN journal
09594965 → ACNP
Volume
11
Issue
6
Year of publication
2000
Pages
1227 - 1230
Database
ISI
SICI code
0959-4965(20000427)11:6<1227:AOTNIG>2.0.ZU;2-2
Abstract
We observed a significant increase in the number subjects carrying the NAT1 *10 allele of the N-acetyl transferase 1 (NAT1) gene in controls with a MAS T-R score of greater than or equal to 4 and in subjects with drug and/or al cohol dependence (p=0.003), compared with controls with a MAST-R <4. These results suggest that alterations in the acetylation of one or more CNS comp ounds may be related to both mild and severe substance abuse. NeuroReport 1 1:1227-1230 (C) 2000 Lippincott Williams & Wilkins.