Temporal profile of release of interleukin-1 beta in neurotrauma

Timing and extent of trauma-induced release of interleukin-1 beta (IL-1 bet a) in extracellular fluid of the CNS were analyzed. In brain tissue perfusa tes obtained by in vivo microdialysis a marked release of IL-1 beta was une xpectedly detected within less than 60 min. At such an early stage of neuro trauma, mRNA expression of IL-1 beta was detected whereas immunoreactivity for the IL-1 beta protein was negative. Concentrations of extracellularly s ecreted IL-1 beta protein gradually increased, peaked at day 2 and decrease d thereafter. Drugs acting on mononuclear phagocytes significantly modulate d IL-1 beta secretion. This so far unrecognized acuity of IL-1 beta release demonstrated here, may represent a precondition for the orchestrating role of this mediator in the cascade of inflammatory host response. (C) 2000 El sevier Science Ireland Ltd. AII rights reserved.