High-pass filtering of carotid-vagal influences on expiration in rat: roleof N-methyl-D-aspartate receptors

Citation
Cs. Poon et al., High-pass filtering of carotid-vagal influences on expiration in rat: roleof N-methyl-D-aspartate receptors, NEUROSCI L, 284(1-2), 2000, pp. 5-8
Citations number
22
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROSCIENCE LETTERS
ISSN journal
03043940 → ACNP
Volume
284
Issue
1-2
Year of publication
2000
Pages
5 - 8
Database
ISI
SICI code
0304-3940(20000421)284:1-2<5:HFOCIO>2.0.ZU;2-L
Abstract
Repetitive electrical stimulation of the carotid sinus nerve or vagus nerve in rats elicited abrupt reflex shortening or prolongation, respectively, o f the inter-burst interval of phrenic nerve activity followed by exponentia l decay from the initial response. Removal of the stimuli resulted in trans ient post-stimulus rebound excitation or inhibition that mirrored the corre sponding stimulus-evoked responses. The biphasic responses to these complem entary inputs approximate the on- and off-transients of full-wave different iators or high-pass filters. Blockade of N-methyl-D-aspartate (NMDA) recept ors abolished the post-stimulus rebounds and transformed both signal pathwa ys into integrators or low-pass filters, thus switching off part or all of the high-pass filters. We suggest that such NMDA receptor-dependent high-pa ss filtering effects may serve to increase the dynamic range and response s peed of sensory neurotransmission to the brain, thereby enhancing closed-lo op stability of sensorimotor reflex. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.