Pyrazole related nucleosides 5. Synthesis and biological activity of 2 '-deoxy-2 ',3 '-dideoxy- and acyclo-analogues of 4-iodo-1-beta-D-ribofuranosyl-3-carboxymethyl pyrazole (IPCAR).

Authors
Manfredini, S Baraldi, PG Bazzanini, R Durini, E Vertuani, S Pani, A Marceddu, T Demontis, F Vargiu, L La Colla, P
Citation
S. Manfredini et al., Pyrazole related nucleosides 5. Synthesis and biological activity of 2 '-deoxy-2 ',3 '-dideoxy- and acyclo-analogues of 4-iodo-1-beta-D-ribofuranosyl-3-carboxymethyl pyrazole (IPCAR)., NUCLEOS NUC, 19(4), 2000, pp. 705-722
Citations number
22
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770 → ACNP
Volume
19
Issue
4
Year of publication
2000
Pages
705 - 722
Database
ISI
SICI code
1525-7770(2000)19:4<705:PRN5SA>2.0.ZU;2-A
Abstract
Continuing our studies on the structure-activity relationships (SAR) of 4-i odo-1-beta-D-ribofuranosyl-3-carboxymethyl pyrazole (IPCAR), the ribofurano syl moiety has been substituted with acyclic chains, namely 1-[(2-hydroxyet hoxy)methyl]- and 1-[(1,3-dihydroxy-2-propoxy)methyl]-pyrazole derivatives (4, 5 and 8, 9 respectively), with the 2'-deoxy-beta-D-ribofuranosyl group (12 and 13) and finally with the 2',3'-dideoxy-D-glycero-pentofuranosyl-moi ety (16 and 17). None of the new compounds display any interesting biologic al activity.