Synthesis of 3 '-O-2-(azaheterocycle)-thymidines

Authors
Prestat, G Dubreuil, D Adjou, A Pradere, JP Lebreton, J Evers, M Henin, Y
Citation
G. Prestat et al., Synthesis of 3 '-O-2-(azaheterocycle)-thymidines, NUCLEOS NUC, 19(4), 2000, pp. 735-748
Citations number
55
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770 → ACNP
Volume
19
Issue
4
Year of publication
2000
Pages
735 - 748
Database
ISI
SICI code
1525-7770(2000)19:4<735:SO3'>2.0.ZU;2-Q
Abstract
The synthesis of 3'-O-2-(azaheterocycle)-thymidines is presented from 1-thi a-3-aza-1,3-butadiene precursors (N-thioacylamidines). A variety of heteroc ycles is accessible using the dienic, the electrophilic or the nucleophilic reactivity of these thia-azabutadiene systems. 3'-O-2-(azaheterocycle)-thy midine analogues are regarded as potential substrates to interfere with the DNA-polymerization process.