Conformation and local environment of nucleotides bound to HIV type 1 reverse transcriptase (HIV-1 RT) in the ground state

Authors
Painter, GR Andrews, CW Furman, PA
Citation
Gr. Painter et al., Conformation and local environment of nucleotides bound to HIV type 1 reverse transcriptase (HIV-1 RT) in the ground state, NUCLEOS NUC, 19(1-2), 2000, pp. 13-29
Citations number
39
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770 → ACNP
Volume
19
Issue
1-2
Year of publication
2000
Pages
13 - 29
Database
ISI
SICI code
1525-7770(2000)19:1-2<13:CALEON>2.0.ZU;2-M
Abstract
Nuclear Overhauser effect experiments were used to characterize the protein environment and conformations of dTTP, dATP and AZTTP bound to HIV-RT in t he ground state. The results show the initial binding sites for the nucleot ides overlap but are not completely coincident. All of the bound nucleotide s assume the same anti C4'-exo conformation.