Synthesis of 4 '-thio-beta-D-arabinofuranosylcytosine (4 '-thio-ara-C) andcomparison of its anticancer activity with that of ara-C

Authors
Tiwari, KN Shortnacy-Fowler, AT Cappellacci, L Parker, WB Waud, WR Montgomery, JA Secrist, JA
Citation
Kn. Tiwari et al., Synthesis of 4 '-thio-beta-D-arabinofuranosylcytosine (4 '-thio-ara-C) andcomparison of its anticancer activity with that of ara-C, NUCLEOS NUC, 19(1-2), 2000, pp. 329-340
Citations number
14
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770 → ACNP
Volume
19
Issue
1-2
Year of publication
2000
Pages
329 - 340
Database
ISI
SICI code
1525-7770(2000)19:1-2<329:SO4'('>2.0.ZU;2-X
Abstract
4'-thio-beta-D-arabinofuranosylcytosine was synthesized by a facile route i n high yields. It was evaluated for antitumor activity against a panel of h uman tumors, both in vitro and in vivo.