Gross type-matched study of clinicopathologic features of advanced gastriccarcinoma with replication error

Sporadic gastric carcinomas with replication error (RER) have been describe d and have distinct clinicopathological features, such as: older age group, predominant antral location, elevated grass type, near-diploidy, expanding pattern (Ming's classification), intestinal type, low desmoplastic respons e, and less frequent lymph node metastasis. Previous study revealed that re plication error-positive (RER+) advanced gastric carcinomas (AGC) had a pre ponderance of Borrmann type 2. Regardless of RER status, AGC of Borrmann ty pe 2 usually exhibit expanding pattern (Ming's classification), intestinal type, and low desmoplastic reaction. Therefore, to better characterize the clinicopathological features of RER+ gastric carcinomas, gross type-matched analysis would be necessary. We analyzed 53 cases of Borrmann type 2 AGC f or RER status using polymerase chain reaction analysis of eight microsatell ite loci and compared the clinicopathological features between RER+ and RER -negative (RER-) tumors. Sixteen (30.2%) out of 53 cases were RER+ phenotyp e which had a significant association with female sex, older age, expanding pattern, small and uniform nuclei, and low DNA index (P < 0.05). However, RER status was not significantly associated with histological differentiati on, histological type (Lauren's classification), desmoplastic response, int ratumoral lymphoid infiltration, and tumor location. Most of the previously known clinicopathological features of RER+ AGC were related to Borrmann ty pe 2, except for female sex, older age, expanding pattern, and low DNA inde x.