Adenocarcinoma at the esophageal gastric junction arising in an 11-year-old girl

Gastric adenocarcinoma is one of the most common gastrointestinal (GI) mali gnancies, especially among Japanese adults, but represents only 0.05% of al l malignant pediatric GI tumors. We report a case of gastric adenocarcinoma arising at the esophageal gastric junction of an Ii-year-old girl. The tum or was polypoid, measuring 3.0 x 3.0 x 1.2 cm and was light gray and partia lly red in color with a stalk, Light microscopic examination of the lesion demonstrated adenocarcinoma of variable degrees of both architectural and n uclear atypia with invasion into the submucosa. Immunohistochemical finding s of cytokeratin subtypes revealed positive immunoreactivity for cytokerati n subtypes 8, 19 and 20 and negative for 5/6/18, 7, 13 and 14, which is con sistent with those of gastric adenocarcinoma. The patient was alive and wel l 12 months postoperatively.