Interaction of divalent metal ions with DNA investigated by Na-23 NMR relaxation

Authors
Marincola, FC Casu, M Saba, G Manetti, C Lai, A
Citation
Fc. Marincola et al., Interaction of divalent metal ions with DNA investigated by Na-23 NMR relaxation, PHYS CHEM P, 2(10), 2000, pp. 2425-2428
Citations number
43
Categorie Soggetti
Physical Chemistry/Chemical Physics
Journal title
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
ISSN journal
14639076 → ACNP
Volume
2
Issue
10
Year of publication
2000
Pages
2425 - 2428
Database
ISI
SICI code
1463-9076(2000)2:10<2425:IODMIW>2.0.ZU;2-N
Abstract
The interaction between Na-DNA and divalent metal cations (Mg2+, Mn2+, Co2 and Ni2+) has been investigated by Na-23 NMR relaxation. The experimental data have been interpreted in terms of Manning's counterion condensation th eory and a two-site exchange for the sodium ions. The experiments showed th at Mn2+ affects the polyion surface atmosphere in a different way from the other metal ions. This behaviour may be due to sugar puckering transition o f the DNA induced by Mn2+.