MODULATION OF MESSENGER-RNA LEVELS IN THE PRESENCE OF THYMOCYTES AND GENOME MAPPING FOR A SET OF GENES EXPRESSED IN MOUSE THYMIC EPITHELIAL-CELLS

Authors
ROCHA D CARRIER A NASPETTI M VICTORERO G ANDERSON E BOTCHERBY M GUENET JL NGUYEN C NAQUET P JORDAN BR
Citation
D. Rocha et al., MODULATION OF MESSENGER-RNA LEVELS IN THE PRESENCE OF THYMOCYTES AND GENOME MAPPING FOR A SET OF GENES EXPRESSED IN MOUSE THYMIC EPITHELIAL-CELLS, Immunogenetics, 46(2), 1997, pp. 142-151
Citations number
41
Categorie Soggetti
Immunology,"Genetics & Heredity
Journal title
Immunogenetics → ACNP
ISSN journal
00937711
Volume
46
Issue
2
Year of publication
1997
Pages
142 - 151
Database
ISI
SICI code
0093-7711(1997)46:2<142:MOMLIT>2.0.ZU;2-8
Abstract
Modulation of gene expression in mouse thymic epithelium upon culture in the presence of thymocytes (coculture) was studied by comparison of hybridization signatures on a set of nearly 5000 mouse thymus cDNA cl ones. Forty-nine differentially expressed clones (usually down-regulat ed in coculture) were characterized by tag sequencing. Many of them co rresponded to entities that had not been described previously in the m ouse, and were further characterized by genome mapping. This set of ge nes appears to be involved in growth regulation and differentiation wi thin the thymus.