Anti-inflammatory activity of coumarins from Decatropis bicolor on TPA earmice model

From the aerial parts of Decatropis bicolor, heraclenin (1), seselin (2), p soralen (3), imperatorin (4), skimmianine (5), and heraclenol (6), were iso lated. This is the first time that coumarin-like compounds are isolated fro m Decatropis genus. The anti-inflammatory properties of compounds 1-6 were examined against the ear edema in mice produced by TPA, The results suggest that the anti-inflammatory activity of each compound depends of its indivi dual substitution on the aromatic ring rather than the coumarin skeleton it self.