Synthesis of oxonium derivatives of the dodecahydro-closo-dodecaborate anion [B12H12](2-). Tetramethylene oxonium derivative of [B12H12](2-) as a convenient precursor for the synthesis of functional compounds for boron neutron capture therapy

Authors
Sivaev, IB Semioshkin, AA Brellochs, B Sjoberg, S Bregadze, VI
Citation
Ib. Sivaev et al., Synthesis of oxonium derivatives of the dodecahydro-closo-dodecaborate anion [B12H12](2-). Tetramethylene oxonium derivative of [B12H12](2-) as a convenient precursor for the synthesis of functional compounds for boron neutron capture therapy, POLYHEDRON, 19(6), 2000, pp. 627-632
Citations number
34
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
POLYHEDRON
ISSN journal
02775387 → ACNP
Volume
19
Issue
6
Year of publication
2000
Pages
627 - 632
Database
ISI
SICI code
0277-5387(20000330)19:6<627:SOODOT>2.0.ZU;2-R
Abstract
Direct synthesis of oxonium derivatives of the dodecahydro-closo-dodecabora te anion is described and the reaction mechanism is discussed. Various deri vatives of the [B12H12](2-) anion containing hydroxyl, amine, acid, and ami no acid functions were prepared by ring opening reactions of the tetramethy lene oxonium derivative [B12H11O(CH2)(4)](-) with different nucleophiles. T his approach is suitable for the development of compounds to be used in tum our selective boron neutron capture therapy (BNCT) and as linkers for the a ttachment of radioactive halogen labels for radioimmunodetection and radioi mmunotherapy. (C) 2000 Elsevier Science Ltd All rights reserved.