A preliminary study of size reduction of powders in a single-vessel pharmaceutical processor

The size reduction performance of a pneumatically driven single-vessel phar maceutical processor is described. Two materials were considered, namely co mmercially available granular lactose (CAGL) and high-speed mixer granulato r lactose (HSMGL). In both cases there is an initial phase in which the par ticle diameter is reduced rapidly. The rate at which the size reduction dec reases is reduced with time. The final particle diameter was found to be de pendent on the material being processed. In the case of CAGL, the minimum s ize achieved was 150 mu m, while in the case of the HSMGL the final particl e diameter was 100 mu m.