Measuring the causal effect of a treatment from observational data is often
difficult because the treatment status of a subject may be confounded with
nonrandomized factors, such as those that affect a subject's choice of tre
atment. An approach to remedying this problem is through the use of instrum
ental variables. We extend the instrumental variables framework proposed by
Angrist, Imbens and Rubin (1996) by introducing a latent "threshold to rec
eive treatment" parameter for each unit in the study. Incorporation of late
nt thresholds in the model permits the inclusion of discrete or continuous
instruments, covariate information, and flexible choices of distributions.
We apply our methodology to examine the effect of cardiac catheterization o
n short-term survival of a cohort of elderly heart attack patients.