Nucleophilic additions to chiral nitrones: New approaches to nitrogenated compounds

The reaction of optically active alpha-alkoxy and alpha-amino nitrones with a variety of nucleophiles serves as a useful process for the stereocontrol led synthesis of enantiomerically pure hydroxylamines having additional fun ctionalities. These hydroxylamines can be used as key intermediates in the synthesis of a wide range of nitrogenated compounds including amino acids, carbohydrates, nucleoside analogs and pyrrolidines.