A synthesis of Cryptophycin 4 using a planar chiral molybdenum cationic complex

Authors
Christopher, JA Kocienski, PJ Kuhl, A Bell, R
Citation
Ja. Christopher et al., A synthesis of Cryptophycin 4 using a planar chiral molybdenum cationic complex, SYNLETT, (4), 2000, pp. 463-466
Citations number
41
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNLETT
ISSN journal
09365214 → ACNP
Issue
4
Year of publication
2000
Pages
463 - 466
Database
ISI
SICI code
0936-5214(200004):4<463:ASOC4U>2.0.ZU;2-Z
Abstract
A synthesis of cytotoxic agent Cryptophycin 4 features a new approach to (5 S,6R)-5-hydroxy-6-methyl-8-phenyl-(2E,7E)-dienoic acid in which the anti st ereochemistry between two stereogenic centres is secured by addition of a 1 ,3-dioxan-4-ylcopper(I) reagent to a planar chiral molybdenum cationic comp lex.