Pd(0) amination of benzimidazoles as an efficient method towards new (benzimidazolyl)piperazines with high affinity for the 5-HT1A receptor

Authors
Lopez-Rodriguez, ML Benhamu, B Ayala, D Rominguera, JL Murcia, M Ramos, JA Viso, A
Citation
Ml. Lopez-rodriguez et al., Pd(0) amination of benzimidazoles as an efficient method towards new (benzimidazolyl)piperazines with high affinity for the 5-HT1A receptor, TETRAHEDRON, 56(20), 2000, pp. 3245-3253
Citations number
55
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
56
Issue
20
Year of publication
2000
Pages
3245 - 3253
Database
ISI
SICI code
0040-4020(20000512)56:20<3245:PAOBAA>2.0.ZU;2-#
Abstract
New (benzimidazolyl)amines have been synthesized from 4- and 6-bromobenzimi dazole derivatives via palladium-mediated amination reactions. Among them, (benzimidazol-4(7)-yl)piperazine derivatives have been shown to be a new fa mily of high affinity 5-HT1A receptor ligands. (C) 2000 Elsevier Science Lt d. All rights reserved.