A new asymmetric 1,4-addition method: application to the synthesis of the HIV non-nucleoside reverse transcriptase inhibitor DPC 961

Authors
Magnus, NA Confalone, PN Storace, L
Citation
Na. Magnus et al., A new asymmetric 1,4-addition method: application to the synthesis of the HIV non-nucleoside reverse transcriptase inhibitor DPC 961, TETRAHEDR L, 41(17), 2000, pp. 3015-3019
Citations number
12
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
17
Year of publication
2000
Pages
3015 - 3019
Database
ISI
SICI code
0040-4039(20000422)41:17<3015:ANA1MA>2.0.ZU;2-X
Abstract
The asymmetric synthesis of the HIV non-nucleoside reverse transcriptase in hibitor (NNRTI) DPC 961 is achieved in three steps with an overall yield of >55%. The asymmetry is induced by the chiral auxiliary (R)-(+)-alpha-methy lbenzylamine, utilizing a new asymmetric 1,4-addition protocol. (C) 2000 Du Pont Pharmaceuticals Company. Published by Elsevier Science Ltd. All rights reserved.