On the biosynthesis of moenocinol, the lipid part of the moenomycin antibiotics

Authors
Schuricht, U Hennig, L Findeisen, M Welzel, P
Citation
U. Schuricht et al., On the biosynthesis of moenocinol, the lipid part of the moenomycin antibiotics, TETRAHEDR L, 41(17), 2000, pp. 3047-3051
Citations number
6
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
17
Year of publication
2000
Pages
3047 - 3051
Database
ISI
SICI code
0040-4039(20000422)41:17<3047:OTBOMT>2.0.ZU;2-B
Abstract
The lipid part of the moenomycins is completely isoprenoid and is construct ed via the non-mevalonate pathway. The central C-10 part originates from a precursor like geranyl or linalyl diphosphate and is formed by a route invo lving ring formation between C-2 and C-6 of the monoterpene unit, two succe ssive rearrangements to give a seven-membered ring intermediate and cleavag e of the ring at the C-5 and C-11 bond (moenocinol numbering). (C) 2000 Els evier Science Ltd. All rights reserved.