Dysidotronic acid, a new and selective human phospholipase A(2) inhibitor from the sponge Dysidea sp.

Authors
Giannini, C Debitus, C Posadas, I Paya, M D'Auria, MV
Citation
C. Giannini et al., Dysidotronic acid, a new and selective human phospholipase A(2) inhibitor from the sponge Dysidea sp., TETRAHEDR L, 41(17), 2000, pp. 3257-3260
Citations number
17
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
17
Year of publication
2000
Pages
3257 - 3260
Database
ISI
SICI code
0040-4039(20000422)41:17<3257:DAANAS>2.0.ZU;2-J
Abstract
A new bioactive sesquiterpenoid, named dysidotronic acid 1, with a rearrang ed drimane skeleton has been isolated from the sponge Dysidea sp. from Vanu atu islands, along with bolinaquinone 2. The chemical structure of 1 was de termined on the basis of spectroscopic data. Dysidotronic acid significantl y inhibited human synovial phospholipase A(2) (PLA(2)) at 10 mu M, with an IC50 value of 2.6 mu M and a higher selectivity and potency towards this en zyme than the reference inhibitor manoalide. (C) 2000 Elsevier Science Ltd. All rights reserved.