Conservation of red blood cells in heterozygous SC sickle cell patients.

In order to evaluate the feasibility of the autologous transfusion in an al loimmunized sickle cell patient, changes in the hematologic and biochemical characteristics of erythrocytes stored for 42 days from two patients with sickle cell SC anemia were compared with control subjects' (Hb A) red blood cells. Erythrocytes were stored in Saline Adenosine Dextrose Mannitol at 4 degrees C. The cryopresentation storage was made and Cr-51 red cell surv ival was measured in one patient. No significant difference in the hematolo gic and biochemical parameters of the SC red blood cells and the control su bjects was observed during the storage at + 4 degrees C. Red cell survivals determined in fresh cells, cells stored for 42 days at + 4 degrees C and t hawed cells from one patient demonstrate much shorter half-life values than those of normal red blood cells. Before application, our results need to b e confirmed by the same protocol with another patient with sickle cell SC. (C) 2000 Editions scientifiques et medicales Elsevier SAS.