The leaves of the Qat plant (Catha edulis Forsk., Celastraceae) which conta
in amphetamine like compounds are widely chewed in Yemen and East Africa fo
r their pleasurable stimulant properties. There are also a number of unwant
ed side-effects and this paper studies the effect on heart rate and blood p
ressure in 80 healthy volunteers. During a 3-h period of chewing fresh Qat
leaves there was a significant and progressive rise in systolic and diastol
ic blood pressure and heart rate, and levels had not returned to baseline 1
h after chewing had ceased. Further studies are needed on possible cardiov
ascular morbidity associated with regular Qat chewing.