Mixed squamous-cell carcinoma with adenocarcinoma of the female urethra. Acase report

We report a case of mixed squamous-cell carcinoma with adenocarcinoma of th e female urethra. A 37 year old women who presented with a 3-month' history of obstructive voiding symptoms. Clinical investigation showed a urethra t umor of 2,5 x 3,5 cm. Needle biopsy revealed a grade 3 carcinoma. Staging r esulted in local cancer disease, a 2,5 x 3,5 cm tumor surrounding the whole urethra with protruding the trigonum. We performed urethrectomy with resec tion of the bladderneck and cystoneostomy. During bladderneck resection we performed regional staging lymphadenectomy of the obturator lymph nodes. Hi stological investigation revealed a mixed squamous-cell carcinoma with aden ocarcinoma and undifferentiated carcinoma of the urethra. Periurethral tiss ue showed lymphangiosis carcinomatosa with negativ lymphnodes. To exclude i nvolvement of regional superficial lymphnodes we subsequently performed mod ified inguinal lymphadenectomy without evidence of advanced cancer disease.