Synthetic studies of the HIV-inhibitive spiroketals - Construction of the C(1)similar to C(8) intermediate of didemnaketals

Authors
Wang, PZ Tu, YQ Li, X
Citation
Pz. Wang et al., Synthetic studies of the HIV-inhibitive spiroketals - Construction of the C(1)similar to C(8) intermediate of didemnaketals, ACT CHIM S, 58(4), 2000, pp. 458-463
Citations number
3
Categorie Soggetti
Chemistry
Journal title
ACTA CHIMICA SINICA
ISSN journal
05677351 → ACNP
Volume
58
Issue
4
Year of publication
2000
Pages
458 - 463
Database
ISI
SICI code
0567-7351(2000)58:4<458:SSOTHS>2.0.ZU;2-A
Abstract
A synthetic procedure for construction of the C(1) similar to C(8) intermed iate of the HIV - inhibitive didemnaketals starting from the natural L - (- ) - menthone was developed, in which two chiral intermediates (3S, 5R, 6S) and (3S, 5R, 6R) - 3 - methyl - 5, 6 - dihydroxy - acetonide - 7 - oxo - oc toate were synthesized, each involved the construction of two extra chiral centers.