A new amidrazone derivative with antimycobacterial activity

Of a series of pyridine-2-carboxamidrazone derivatives with activity agains t mycobacteria, the N-1-[4-(1,1-dimethylpropyl)benzylidene] derivative repo rted here, C18H22N4, is one of the most active. The predicted E isomer abou t the C11=N12 double bond is confirmed and intramolecular hydrogen bonding involving both amino H atoms helps to keep the molecule flat. The same dono r and acceptor atoms also form intermolecular hydrogen bonds.