Our purpose was to measure quality of life (QOL) and work productivity
(WP) in persons with panic disorder. Eighty-four panic disorder patie
nts with limited psychiatric comorbidity from ten U.S. outpatient ment
al health centers were evaluated in a cross-sectional design. Patients
self-administered the Medical Outcomes Study 36-Item Short Form Healt
h Survey (SF-36) and Work Productivity and Impairment (WPAI) questionn
aire. The independent effects of psychiatric comorbidity were addresse
d through entry criteria, stratification, and regression analyses. QOL
scores are significantly below age and sex-adjusted population norms
on all SF-36 measures (p < .01). We note far greater impairment on mea
sures of mental and emotional versus physical well-being. The unemploy
ment rate among these patients is 25%, and only 57% are employed full-
time. Those who are employed rated their WP as low. This sample of out
patients suffer marked QOL and employment impairment, which is only pa
rtially explained by the presence of psychiatric comorbidity.