Fine needle aspiration cytology of well-differentiated liposarcoma - A report of two cases

BACKGROUND: Well-differentiated liposarcoma is difficult to diagnose on fin e needle aspiration cytology (FNAC) smears and may create considerable diag nostic problems. CASES: Males aged 60 and 45 years presented with a swelling in the groin an d retroperitoneal region, respectively. FNAC showed large cells with multil obulated nuclei and mature-looking fat tissue. A soft tissue tumor with biz arre cells was diagnosed cytologically in case 1 and liposarcoma in case 2. Histologically, both cases were diagnosed as well-differentiated sclerosin g liposarcoma. CONCLUSION: The cytologic diagnosis of well-differentiated liposarcoma shou ld be done with caution, and the sites should be taken into consideration. Deep-seated tumors with large, bizarre, giant cells should have wide excisi on as they recur more frequently.