Role of the sympathetic nervous system during the development of obesity-induced hypertension in rabbits

We have previously reported that weight gain induced by high-fat diet (HFD) leads to an increase in mean arterial pressure (MAP, +14%) and heart rate (HR, +31%) in the adult rabbit. In the present study, we tested the hypothe sis that an increased activity of the sympathetic nervous system may contri bute to the development of obesity-induced hypertension. A combination of a lpha- and beta-adrenergic blockers (terazosin + propranolol) was chronicall y administered to rabbits housed in metabolic cages for continuous monitori ng of arterial pressure by telemetry, 24 h a day. After 2 weeks of adrenerg ic blockade under control diet, animals were switched to HFD for the next 6 weeks. HFD induced a progressive increase in body weight, but no increase in mean arterial pressure (+0.2 +/- 2.5%) and a slight increase in heart ra te (+14 +/- 3%). Time-control animals fed normal diet showed no changes in MAP or HR with long-term alpha- and beta-adrenergic blockade. Our results i ndicate that the activation of the sympathetic nervous system may play an i mportant role in the pathogenesis of obesity-induced hypertension. (C) 2000 American Journal of Hypertension, Ltd.