Japanese monozygotic twins with familial amyloidotic polyneuropathy (FAP) (ATTR Val30Met)

Authors
Ando, Y Ohtsu, Y Terazaki, H Kibayashi, K Nakamura, M Ando, E Matsunaga, N Obayashi, K Uchino, M Ando, M Tsunenari, S
Citation
Y. Ando et al., Japanese monozygotic twins with familial amyloidotic polyneuropathy (FAP) (ATTR Val30Met), AMYLOID, 7(2), 2000, pp. 133-136
Citations number
19
Categorie Soggetti
Medical Research General Topics
Journal title
AMYLOID-INTERNATIONAL JOURNAL OF EXPERIMENTAL AND CLINICAL INVESTIGATION
ISSN journal
13506129 → ACNP
Volume
7
Issue
2
Year of publication
2000
Pages
133 - 136
Database
ISI
SICI code
1350-6129(200006)7:2<133:JMTWFA>2.0.ZU;2-F
Abstract
Twenty-nine-year-old twin brothers having the amyloidogenic transthyretin ( ATTR) Val30Met gene developed the clinical symptoms of familial amyloidotic polyneuropathy (FAP) in 1995. The twins had the same educational backgroun d and lived in the same district. FAP manifestations were similar in both c ases, although electromyographic examinations revealed sensorimotor polyneu ropathy in No. 1 and sensory polyneuropathy in No. 2. DNA analysis revealed that they were monozygotic twins. In addition to environmental factors, ge netic factors may play an important role in determining the onset of FAP.