Retrospective analysis of rt-pa thrombolysis combined with PGE(1) in patients with peripheral arterial occlusions

Although thrombolysis has been established for recanalization of acute and in part chronic peripheral artery occlusions, only smaller studies exist re garding the use of longterm rt-pa infiltration-thrombolysis. The objective of this study was to evaluate the benefit of additional long-term thromboly sis in patients with peripheral arterial occlusions for whom acute thrombol ysis failed. From 1992 to 1997, 323 patients with peripheral arterial occlu sions were treated with rt-pa (recombinant tissue-type plasminogen activato r). When the thrombolysis failed during the first 3 hours, the thrombolytic therapy was continued as a long-term treatment with 3 mg rt-pa alternated by PGE, (2.1 mL/hr for 3 hours, concentration: 20 mu g/50 mL NaCl) every 3 hours. Additional heparin was applied in doses of 15,000 IE/24 hr or more t o slightly increase the partial thromboplastin time. Angiographic controls were performed every 24 hours. If necessary, a final angioplasty was perfor med. In 142 of the 323 patients the occlusions were recanalized during the first 3 hours; 119 patients were treated with a long-term thrombolysis and in 72 (61%) a recanalization was ultimately achieved. Thus, the recanalizat ion rate increased to 214 of 323 patients (p < 0.02). Mean treatment time w as 2.8 +/- 2.2 days, range: 1 to 13 days. The rates of recanalization were not different in iliac, femoral, or crural arteries. Fibrinogen levels did not decrease during thrombolysis. Severe bleeding (with a decrease of more than 3 g/dL hemoglobin requiring transfusion) occurred in four patients aft er finishing the thrombolysis with short-term and in six with long-term the rapy; two required surgical treatment. The 1-, 2-, and 3-year cumulative pa tency rates were respectively 90.1%, 74.2% and 64.9%. Patency rates in pati ents with acute or long-term thrombolysis were not different. A composite t hrombolytic treatment using low-dose rt-pa in combination with PGE(1) offer s significantly better results than an acute thrombolytic treatment alone. It can be an effective and practicable regimen in about 60% of patients in whom acute thrombolysis fails.