Serum uric acid and risk of coronary heart disease: Atherosclerosis risk in communities (ARIC) study

PURPOSE: Approximately half of previous studies on serum uric acid have rep orted if to br an independent risk factor for coronary heart disease (CHD). We tested this hypothesis in the Atherosclerosis Risk in Communities (ARIC ) Study. METHODS: A total of 13,504 healthy middle-aged men and women were followed prospectively for up to eight years. We identified 128 fatal and nonfatal C HD events in women and 264 in men. RESULTS: The age-, race-, and ARIC field center-adjusted relative risk of C HD for sex-specific quartiles of serum uric acid were 1.0, 1.39, 1.08, and 2.35 in women (p for trend = 0.009) and 1.0, 1.03, 0.89, and 1.21 in men (p for trend = 0.44), respectively. However, serum uric acid was correlated p ositively with many risk factors, and after multivariable adjustment, there was little evidence of an association of uric acid with CHD in either sex. CONCLUSIONS: Our results are not consistent with serum uric acid being an i ndependent risk factor for CHD. Ann Epidemiol 2000;10:136-143. (C) 2000 Els evier Science Inc. All rights reserved.