Non-lipid-related effects of statins

The beneficial effects of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) r eductase inhibitors (statins) on coronary events have generally been attrib uted to their hypocholesterolaemic properties. However, as mevalonate and o ther intermediates of cholesterol synthesis (isoprenoids) are necessary for cell proliferation and other important cell functions, effects other than cholesterol reduction may explain the pharmacological properties of statins . In the present review, we discuss the current knowledge on the nonlipid-r elated effects of statins, with a special emphasis on their potential benef its in different diseases, such as atherosclerosis and cancer. The mechanis m(s) responsible for their favourable properties are also reviewed.