A branchial remnant originating in the pyriform sinus causes a recurrent fi
stula or abscess in the neck. In spite of excision, recurrence may result f
rom inadequate removal of the fistula tract. We attempted chemocauterizatio
n of the internal opening of the fistula tract with trichloroacetic acid (T
CA) on direct endoscopy. This is a 6-year review of 18 patients with pyrifo
rm sinus fistula. Medical history, barium esophagography, computed tomograp
hy scans, operative findings, and treatment results were analyzed. By direc
t endoscopy, all patients were found to have a fistula opening in the pyrif
orm sinus. exclusively on the left side. In only 9 patients, the fistula tr
act was identified by barium esophagography before operation. Computed tomo
graphy revealed a suspicious fistula tract originating from the pyriform si
nus in 8 of 10 patients. Sixteen patients were initially managed by TCA che
mocauterization. There were no serious intraoperative or postoperative comp
lications. Four patients had recurrent masses, which were managed by simple
excision in 2 patients and repeated TCA cauterization in the other 2 patie
nts with unobliterated internal openings. We recommend barium swallow study
and direct endoscopy for all patients presenting with a recurrent lateral
neck abscess, especially on the left side. Our results suggest that initial
chemocauterization of the internal opening can be a reasonable alternative
procedure for the management of pyriform sinus fistula.