The availability of brief screening instruments encourages their routine us
e in identifying individuals who are presumed to be at risk for clinical de
pression. In primary medical care where this idea has been most tested, how
ever, there is little evidence that screening by itself improves the outcom
e of depression. Reasons why screening cannot serve as an efficient basis f
or the prevention of depression are reviewed. Moreover, a positive score on
a screening instrument does not indicate a clear need for intervention or
the form that any intervention should take. Routine screening should be und
ertaken only when the resources are available for interpreting the signific
ance of positive screen scores, appropriate and acceptable interventions ar
e available, and potential negative effects of screening can be avoided. Un
til these conditions can be met, alternatives to screening should be consid
ered.