Lipid peroxidation and glutathione system in hyperlipemic rabbits: influence of olive oil administration

Citation
Jp. De La Cruz et al., Lipid peroxidation and glutathione system in hyperlipemic rabbits: influence of olive oil administration, BBA-MOL C B, 1485(1), 2000, pp. 36-44
Citations number
30
Categorie Soggetti
Biochemistry & Biophysics
Journal title
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
ISSN journal
13881981 → ACNP
Volume
1485
Issue
1
Year of publication
2000
Pages
36 - 44
Database
ISI
SICI code
1388-1981(20000506)1485:1<36:LPAGSI>2.0.ZU;2-C
Abstract
We studied the effect of supplementation (10% w/w) of a hyperlipemic diet ( 1% cholesterol) with olive oil (OLIV) for 6 weeks in four groups of 10 rabb its each. At the end of this period, we determined lipid peroxidation, glut athione content, and glutathione peroxidase, reductase and transferase acti vities in liver, brain, heart, aorta and platelets. The atherogenic diet in creased tissue lipid peroxidation and decreased the protective antioxidant effect of glutathione. Dietary supplementation with olive oil reduced tissu e lipid peroxidation by 71.6% in liver, 20.3% in brain, 84.5% in heart, 63. 6% in aorta, 72% in platelets. The ratios total/oxidized glutathione were i ncreased in all tissues (49% in liver, 48% in brain, 45% in heart, 83% in a orta, 70% in platelets). Olive oil increased glutathione peroxidase and tra nsferase activities in all tissues. We conclude that in rabbits made hyperl ipemic with a diet rich in saturated fatty acids, olive oil decreased tissu e oxidative stress. (C) 2000 Elsevier Science B.V. All rights reserved.