Purpose: To evaluate the effectiveness of two-incision radial keratoto
my (RK) in correcting low-magnitude refractive myopic astigmatism. Set
ting: Two clinical study sites, one in St. Louis, Missouri, USA, the o
ther in Caracas, Venezuela. Methods: Fifty-seven eyes of 43 patients w
ith low-magnitude myopic astigmatism had two-incision RK at one of two
clinical study sites. In the initial phase of this series, 10 eyes wi
th amblyopia at the 20/30 level had surgery at one center. Refractive
keratotomy was performed with the radial incision placed in the plus c
ylinder axis of refraction. This axis was verified as the meridian of
greatest corneal curvature by standard keratometry and computer-assist
ed corneal topographic analysis. Two eyes received a second operation
(enhancement).Results: Mean follow-up was 11.1 months (range 6 to 12 m
onths). Mean preoperative and postoperative myopic spherical equivalen
t measured -1.42 diopters (D) +/- 0.51 (SD) and -0.14 +/- 0.39 D, resp
ectively; the mean reduction was 1.28 +/- 0.59 D (P = .0001). Mean pre
operative and postoperative refractive astigmatism was 1.41 +/- 0.45 D
and 0.48 +/- 0.33 D, respectively (P = .0001). Mean preoperative and
postoperative keratometric astigmatism was 1.26 +/- 0.54 D and 0.31 +/
- 0.35 D, respectively, a mean reduction of 0.95 D (P = .0001). The su
rgical meridian was flattened by an average of 2.06 D by keratometry a
nd the orthogonal meridian, by an average of 1.10 D. Preoperative unco
rrected visual acuity (UCVA) was 20/40 or better in five (9%) eyes (ra
nge counting fingers to 20/40). Postoperative UCVA acuity was 20/40 or
better in all eyes (mean acuity 20/25). In the nonamblyopic subgroup,
mean postoperative UCVA was 20/24. Conclusions: A limited number of r
adial incisions placed in the topographically confirmed axis of greate
st curvature are effective in the treatment of low-magnitude myopic as
tigmatism.