Cytogenetics of epithelial hyperplasias of the human breast

Citation
Rr. Burbano et al., Cytogenetics of epithelial hyperplasias of the human breast, CANC GENET, 119(1), 2000, pp. 62-66
Citations number
20
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
CANCER GENETICS AND CYTOGENETICS
ISSN journal
01654608 → ACNP
Volume
119
Issue
1
Year of publication
2000
Pages
62 - 66
Database
ISI
SICI code
0165-4608(200005)119:1<62:COEHOT>2.0.ZU;2-D
Abstract
Generally, benign breast lesions behave like innocuous and limited prolifer ations; however, sometimes they can represent precancerous pathologies. The cytogenetic analysis of five mammary epithelial hyperplasias is reported. Four cases had clonal chromosome alterations. All of the cases presented a modal number of 46 chromosomes. Chromosome 9 monosomies and chromosome 1 de letions were common in these benign tumors. The study of benign proliferati ons of the breast may reveal a possible relationship between chromosomal al terations and the conditions of the tissue. (C) 2000 Elsevier Science Inc. All rights reserved.