Generally, benign breast lesions behave like innocuous and limited prolifer
ations; however, sometimes they can represent precancerous pathologies. The
cytogenetic analysis of five mammary epithelial hyperplasias is reported.
Four cases had clonal chromosome alterations. All of the cases presented a
modal number of 46 chromosomes. Chromosome 9 monosomies and chromosome 1 de
letions were common in these benign tumors. The study of benign proliferati
ons of the breast may reveal a possible relationship between chromosomal al
terations and the conditions of the tissue. (C) 2000 Elsevier Science Inc.
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