A novel translocation (17;19)(p13;p13) in a patient with acute myelomonocytic leukemia

Authors
Bruckner, R Jentsch-Ullrich, K Franke, A Wieacker, P Stumm, M
Citation
R. Bruckner et al., A novel translocation (17;19)(p13;p13) in a patient with acute myelomonocytic leukemia, CANC GENET, 119(1), 2000, pp. 77-79
Citations number
6
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
CANCER GENETICS AND CYTOGENETICS
ISSN journal
01654608 → ACNP
Volume
119
Issue
1
Year of publication
2000
Pages
77 - 79
Database
ISI
SICI code
0165-4608(200005)119:1<77:ANT(IA>2.0.ZU;2-1
Abstract
We report on a patient with acute myeloid leukemia (AML M4) and a so far un recorded translocation (17;19). The leukemia transformed from a myeloprolif erative disorder (MPD) and showed ct progressive fatal course. Following tr ansformation, all leukemic cells showed an apparently balanced translocatio n (17;19)(p13;p13). The breakpoint regions harbor genes such as TP53 (17p13 ) and E2A, ENL, or LYL1 (19p13), which could be relevant in leukemogenesis. We suspect that the translocation (17;19) (p13;p13) may be a prognostic fa ctor for transformation from chronic MPD to acute leukemia. (C) 2000 Elsevi er Science Inc. All rights reserved.