Membranous glomerulonephritis in a patient with inherited activated protein C resistance

We present a patient with membranous glomerulonephritis, several clinical c omplications of the antiphospholipid syndrome and ulcerative colitis, but w ithout lupus anticoagulant and antiphospholipid/cofactor antibodies. Immuno logical studies - other antibodies - were negative and failed to show enoug h criteria for any autoimmune diseases. Evaluation of her laboratory tests for hereditary thrombophilia revealed a heterozygous form of the Leiden mut ation that might be associated with widespread vasculopathy, An interesting possibility is that the inherited activated protein C resistance could be an additional risk factor for vaso-occlusive manifestations appearing as a clinical sign of cardiovascular diseases and nephropathy.