Successful management of polyneuropathy associated with IgM gammopathy of undetermined significance with antibody-based immunoadsorption

Peripheral polyneuropathies associated with monoclonal IgM gammopathy of un determined significance often have a progressive course and optimal treatme nt has not been established. We report on a patient diagnosed with polyneur opathy associated with benign IgM gammopathy, who was successfully treated with antibody-based immunoadsorption only. The neurological symp toms of th e patient improved continuously over six months of treatment. Controlled tr ials should be performed to define this indication for antibody-based immun oadsorption therapy.