The beneficial effects of calcium channel blockers on long-term kidney transplant survival are independent of blood-pressure reduction

There is a growing body of evidence suggesting that calcium channel blocker s (CCB) exert beneficial effects on kidney transplant survival. However, it is not completely understood if these agents act independently of blood-pr essure reduction. In the present study, the 5-yr follow-up of 45 kidney tra nsplant recipients receiving CCB during the 60-month follow-up period was c ompared to that of recipients with lower blood pressure and an antihyperten sive treatment without CCB. During the whole follow-up, systolic (127.4 +/- 2.5 vs. 139.4 +/- 2.1 mmHg, p<0.05) as well as diastolic blood pressure (7 8.8 +/- 1.1 vs. 84.8 +/- 1.8 mmHg, p<0.05) was higher in the group receivin g CCB. Moreover, in CCB-treated recipients, a significant (p<0.05) higher i ncrease in proteinuria was detected (from 759 +/- 120 to 1690 +/- 359 mg/24 h vs. 180 +/- 45 to 340 +/- 45 mg/24 h). Despite higher blood pressure and higher proteinuria, the increase in serum creatinine in the group of CCB-t reated recipients was significantly lower (0.01 mg/dL/month) in comparison to that of the controls (0.02 mg/dL/month, p<0.05). Moreover, the 5-yr tran splant survival was significantly higher in CCB-treated recipients (62.3 vs . 31.8%, p<0.05). The results of the present study further support the bene ficial effects of CCB in kidney transplant recipients, which are independen t of blood-pressure reduction.