Reproducibility of volumetric macular measurements in diabetic patients with the Heidelberg Retina Tomograph

Citation
Hj. Zambarakji et al., Reproducibility of volumetric macular measurements in diabetic patients with the Heidelberg Retina Tomograph, DOC OPHTHAL, 97(3-4), 1999, pp. 349-360
Citations number
17
Categorie Soggetti
Optalmology
Journal title
DOCUMENTA OPHTHALMOLOGICA
ISSN journal
00124486 → ACNP
Volume
97
Issue
3-4
Year of publication
1999
Pages
349 - 360
Database
ISI
SICI code
0012-4486(1999)97:3-4<349:ROVMMI>2.0.ZU;2-L
Abstract
Aims: To quantify diabetic macular edema by confocal scanning laser ophthal moscopy and assess its usefulness by determining the reproducibility of top ographic measurements at the macula. Methods: The volumes above reference p lane bound by a 2 mm diameter circle centred on the fovea were measured by two observers. The reference plane was adjusted to the lowest point of the height variation of the contour line. The reproducibility of this technique was assessed in 20 eyes of 20 diabetic patients of which 8 eyes had macula r edema. Three HRT scans of each eye were obtained. The measurements of vol ume above reference plane of each scan were repeated three times. Results: For all diabetic eyes, the intra scan coefficients of variability measured 14.71% to 21.21%, the inter scan coefficient of variability was 30.46%. The average standard deviations were 0.053 mm(3) for one examination per scan, 0.047 mm(3) for two examinations per scan and 0.044 mm(3) for three examin ations per scan. Linear regression demonstrated an increase in standard dev iation with greater volumetric measurements (p < 0.001). We found good corr elation (r = 0.959, p < 0.001) and strong agreement between the two observe r's findings for all 20 eyes. For the 8 eyes with macular edema, the coeffi cients of variability were similar to those calculated for all 20 eyes. The average SD for one examination per scan were 0.078 mm(3), 0.069 mm(3) for two examinations per scan and 0.062 mm(3) for three examinations per scan. We found good correlation (r = 0.945, p < 0.001) and strong agreement betwe en the two observer's findings in eyes with edema. Conclusion: The reproduc ibility of this technique has been demonstrated in diabetic eyes. This may have useful clinical applications for the quantification of diabetic macula r edema and monitoring of laser therapy.