Medical treatment of macular edema in patients with uveitis

Citation
B. Rojas et al., Medical treatment of macular edema in patients with uveitis, DOC OPHTHAL, 97(3-4), 1999, pp. 399-407
Citations number
15
Categorie Soggetti
Optalmology
Journal title
DOCUMENTA OPHTHALMOLOGICA
ISSN journal
00124486 → ACNP
Volume
97
Issue
3-4
Year of publication
1999
Pages
399 - 407
Database
ISI
SICI code
0012-4486(1999)97:3-4<399:MTOMEI>2.0.ZU;2-B
Abstract
Purpose: To determine the efficacy of medical treatment of cystoid macular edema (CME) in patients with uveitis. Methods: Retrospective study of 40 pa tients (57 eyes) with uveitis and CME. Inclusion criteria were presence of CME with minimal and no macular pathology, or vascular disease which could account for CME. Patients who had undergone intraocular surgery or had visu al aucity (VA) of greater than or equal to 20/40 were excluded. The diagnos is of CME was based on clinical and/or angiographic findings. Three treatme nt groups were defined: (1) transseptal injection of steroids (n=13 eyes); (2) systemic non steroidal anti-inflammatory drugs (NSAIDs) (n=11 eyes); bo th 1 and 2 (n=33 eyes). Results: Overall, 79% of eyes improved 3 or more li nes of Snellen VA after treatment: 51% improved 4 or more lines. The averag e number of lines improved was 3.8 for eyes treated with transseptal inject ions of steroids, 2.9 for eyes treated with NSAIDs, and 4 for eyes treated with both. For all 3 treatment groups between 60-70% of eyes improving 2 or more lines reached best VA only after a minimum of 6 months of follow up. Conclusions: CME, a vision threatening complication of uveitis, respond fai rly well to medical treatment; however, the best VA is achieved after sever al months. The improvement in VA did not differ markedly among the three tr eatment groups.