The purpose of this study was to evaluate the role of vitrectomy with cysto
tomy in the treatment of diabetic cystoid macular edema (CME). Among 22 eye
s of 21 patients with diabetic CME underwent phacoemulsification, intraocul
ar lens implantation, pars plana vitrectomy, induction of posterior vitreou
s detachment, and cystotomy or cystectomy. Follow-up ranged from 3 to 29 mo
nths. Under biomicroscopic examination, Cystoid macular edema was eliminate
d in 16 of 22 eyes during the follow-up period. Ring-shaped residual edema
was observed in one eye. Corrected visual acuity improved in 7 of 22 eyes b
y more than one Snellen line (P = 0.0391, paired t-test), remained the same
in 13 eyes, and decreased by more than one line in 2 eyes. This pilot stud
y shows that cystotomy may have a role in the treatment of cystoid macular
edema in diabetic patients.